Congenital Hypothyroidism: An Unusual Combination of Biochemical Abnormalities

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Congenital Hypothyroidism: An Unusual Combination of Biochemical Abnormalities

A forty-five-day-old female infant presented with prolonged jaundice with clinical features suggestive of congenital hypothyroidism (CHT). On investigations, the infant was noted to have indirect hyperbilirubinemia (13.8 mg/dl) with increased levels of AST (298 IU/dl) and ALT (174 IU/dl) in the serum. The child had low levels of free T3 (<1 pg/ml) and free T4 (0.4 ng/dl) secondary to thyroid ag...

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Hypothyroidism is usually associated with delayed pubertal development but in rare occasions precocious puberty may ensue which is seen in cases of prolonged and untreated hypothyroidism. This is also called the Van Wyk Grumbach syndrome. Here we present 4 cases of precocious puberty due to hypothyroidism.

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Congenital urogenital abnormalities in children with congenital hypothyroidism

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precocious puberty: an unusual presentation of hypothyroidism

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ژورنال

عنوان ژورنال: Case Reports in Pediatrics

سال: 2016

ISSN: 2090-6803,2090-6811

DOI: 10.1155/2016/2678578